簡(jiǎn)介:中國非公立醫療機構協(xié)會(huì )病理學(xué)專(zhuān)委會(huì )常委及血液病學(xué)組組長(cháng) 。
擅長(cháng):血液病的分子診斷和研究 。
專(zhuān)業(yè)經(jīng)驗:
從事臨床醫師工作3年,血液病實(shí)驗診斷及相關(guān)研究工作22年。在白血病發(fā)病機制、新白血病分子分型鑒定、基因突變分型等方面有多項國際原創(chuàng )性發(fā)現。以通訊/第一作者于Nature Medicine、Blood等中英文期刊發(fā)表學(xué)術(shù)論文150余篇。所指導的工作和培養的團隊成員于A(yíng)SH、ASHG、JSH等國際學(xué)術(shù)會(huì )議做Oral、Poster會(huì )議報告120余人次。
執業(yè)經(jīng)歷:
2022- 北京陸道培血液病研究院 執行院長(cháng)
2018-2021 北京陸道培血液病研究院 副院長(cháng)
2017- 北京陸道培醫院、河北燕達陸道培醫院 病理和檢驗醫學(xué)科 主任
2015-2016 河北燕達陸道培醫院 病理和檢驗醫學(xué)科 主任
2012-2015 陸道培血液?腫瘤中心 醫學(xué)檢驗科 主任
2011-2012 北京市道培醫院 檢驗中心 副主任
2006-2011 北京市道培醫院 分子診斷室 分子診斷臨床應用和研究
2003-2006 北京大學(xué)工學(xué)院 生物醫學(xué)工程專(zhuān)業(yè) 碩士
2000-2003 山東省日照市東港區婦幼保健院 臨床醫師
1995-2000 濱州醫學(xué)院 臨床醫學(xué)專(zhuān)業(yè) 學(xué)士
社會(huì )職稱(chēng):
第七屆北京優(yōu)秀醫師;中國非公立醫療機構協(xié)會(huì )病理學(xué)專(zhuān)委會(huì )常務(wù)委員兼血液病學(xué)組組長(cháng)、中國醫藥衛生文化協(xié)會(huì )實(shí)驗診斷與社會(huì )化服務(wù)專(zhuān)委會(huì )常務(wù)委員、中國非公立醫療機構協(xié)會(huì )檢驗醫學(xué)專(zhuān)委會(huì )常務(wù)委員、中國抗癌協(xié)會(huì )腫瘤基因診斷專(zhuān)委會(huì )/臨床檢驗與伴隨診斷專(zhuān)委會(huì )/腫瘤疫苗專(zhuān)委會(huì )委員、北京非公立醫療機構協(xié)會(huì )檢驗專(zhuān)委會(huì )副主任委員、北京免疫學(xué)會(huì )理事等;國家病理質(zhì)控中心非公組專(zhuān)家;河北省臨床檢驗中?室間質(zhì)量評價(jià)專(zhuān)家委員會(huì )員;《中華醫學(xué)雜志》通訊編委;《白血病?淋巴瘤》、《分子診斷與治療雜志》、Proceedings of Anticancer Research 、International Journal of Medical Reviews 編委。
發(fā)明專(zhuān)利:
劉紅星,朱平,王倩,蔡鵬,童春容. 一種用于檢測細胞嵌合狀態(tài)或個(gè)體識別的基因檢測試劑盒. 專(zhuān)利號:CN101671736B
劉紅星,滕文,王芳,張陽(yáng),陳雪. 白血病融合基因篩查檢測方法. 專(zhuān)利申請號:CNL201710580828.2
劉紅星,滕文,王芳,張陽(yáng),陳雪. 白血病融合基因篩查檢測試劑盒. 專(zhuān)利申請號:CNL201710581443.8
劉紅星,王彤,滕文. 用于PCR擴增的標本及其制備方法、保存方法和使用方法. 專(zhuān)利申請號:CNL201710845441.5
專(zhuān)業(yè)/培訓證書(shū)
國家醫師執業(yè)資格證書(shū)
二級實(shí)驗室生物安全培訓證書(shū)
遺傳咨詢(xún)師證書(shū)
藥物臨床試驗質(zhì)量管理規范(GCP)培訓證書(shū)
所獲獎勵
2014.10 第76屆日本血液學(xué)年會(huì )Travel Award 日本血液學(xué)會(huì )
2013.10 第75屆日本血液學(xué)年會(huì )Travel Award 日本血液學(xué)會(huì )
2012.10 第74屆日本血液學(xué)年會(huì )Travel Award 日本血液學(xué)會(huì )
2011.10 第73屆日本血液學(xué)年會(huì )Travel Award 日本血液學(xué)會(huì )
2011.1 2010年度科研創(chuàng )新獎 北京市道培醫院
2010.9 第72屆日本血液學(xué)年會(huì )Travel Award 日本血液學(xué)會(huì )
2010.3 2009年度最佳學(xué)術(shù)論文獎 北京市道培醫院
2009.1 2008年度優(yōu)秀員工 北京市道培醫院
2008.1 2007年度突出貢獻員工(第一名) 北京市道培醫院
2008.1 2007年度開(kāi)拓創(chuàng )新獎 北京市道培醫院
編著(zhù)及論文:
學(xué)術(shù)論文(近3年) @通訊/共同通訊作者;#共同第一作者
1.@王芳, 房建成, 許媛麗, 李婷婷,劉紅星. 三種統計指標在 IGH 免疫組庫分析中的應用. 中國免疫學(xué)雜志, 2018.34(11):1720-3. [DOI: 10.3969/j.issn.1000-484X.2018.11.025]
2.@王磊, 孫文利, 劉紅星. 高效液相色譜-串聯(lián)質(zhì)譜法測定移植患者血漿泊沙康唑水平. 檢驗醫學(xué)與臨床, 2018.15(19):2902-5. [DOI: 10.3969/j.issn.1672-9455.2018.19.017]
3.@Xue Chen, Fang Wang, Yang Zhang, et al. Panoramic view of common fusion genes in a large cohort of Chinese de novo acute myeloid leukemia patients, Leukemia & Lymphoma. 2018, Online Published. [DOI: 10.1080/10428194.2018.1516876] [PMID: 30277115]
4.@Yang Zhang, Fang Wang, Xue Chen, et al. Mutation profiling of 16 candidate genes in de novo acute myeloid leukemia patients. Front. Med. 2018, Online Published. [DOI:10.1007/s11684-018-0616-1] [PMID: 29806051]
5.@Xue Chen, Fang Wang, Yang Zhang, et al. Retrospective analysis of 36 fusion genes in 2,479 Chinese patients of de novo acute lymphoblastic leukemia. Leukemia Research. 2018(72):99-104. [DOI:10.1016/j.leukres.2018.08.009] [PMID: 30125757]
6.@Yang Zhang, Fang Wang, Xue Chen, et al. CSF3R mutations are frequently associated with abnormalities of RUNX1, CBFB, CEBPA, and NPM1 genes in acute myeloid leukemia. Cancer. 2018, 124(16):3329-38. [DOI: 10.1002/cncr.31586] [PMID:29932212]
7.@Xue Chen, Fang Wang, Yang Zhang, et al. Genetic variant spectrum in 265 Chinese patients with hemophagocytic lymphohistiocytosis: molecular analyses of PRF1, UNC13D, STX11, STXBP2, SH2D1A, and XIAP. Clinical Genetics. 2018, 94(2):200-12. [DOI: 10.1111/cge.13363] [PMID: 29665027]
8.@陳雪, 王芳, 房建成, 等. 595例初診兒童急性髓系白血病患者36種融合基因篩查分析[J]. 臨床與病理雜志,2018,38(6):1202-7. [DOI:10.3978/j.issn.2095-6959.2018.06.011]
9.@王磊, 劉紅星. HPLC-MS/MS法測定患者血漿中伊曲康唑和羥基伊曲康唑濃度[J]. 臨床合理用藥雜志,2018,11(6):4-6.
10.@王磊, 劉紅星. 應用HPLC-MS/MS法測定骨髓移植患者的血漿伏立康唑濃度[J]. 中國實(shí)用醫刊,2018,45(9):30-3. [DOI:10.3760/cma.j.issn.1674-4756.2018.09.010]
11.@張建平, 楊君芳, 王芳, 等. 1392例初診兒童急性淋巴細胞白血病患者36種融合基因篩查分析[J]. 臨床與病理雜志,2018,38(5):956-60. [DOI:10.3978/j.issn.2095-6959.2018.05.008]
12.@王磊,孫文利,李培余,等. Elecysis與HPLC-MS/MS檢測骨髓移植患者環(huán)孢素A血藥濃度的相關(guān)性及其應用意義[J]. 中華臨床實(shí)驗室管理電子雜志,2018,6(2):99-103. [DOI: 10.3877/cma.j.issn.2095-5820.2018.02.007]
13.@王磊,姜春菲,甄成亮,等. 白血病患者伏立康唑血藥濃度監測的回顧性研究[J]. 中華臨床醫師雜志(電子版),2018,12(3):156-9. [DOI:10.3877/cma.j.issn.1674-0785.2018.03.007]
14.@王磊,劉紅星. 高效液相色譜-串聯(lián)質(zhì)譜法測定患者血漿萬(wàn)古霉素濃度[J]. 臨床檢驗雜志(電子版), 2018,7(1):17-19.
15.@王磊,王紅春,李培余,等. 兩種檢測骨髓移植患者環(huán)孢素A血藥濃度方法的比較[J]. 中華臨床實(shí)驗室管理電子雜志,2017,5(4):240-4. [DOI: 10.3877/cma.j.issn.2095-5820.2017.04.010]
16.@劉銘,張陽(yáng),王芳,等. 骨髓增生異常綜合征患者常見(jiàn)突變基因的突變組分析[J]. 臨床與病理雜志,2017,37(11):2332-8. [DOI:10.3978/j.issn.2095-6959.2017.11.008]
17.@Xue Chen, Yang Zhang, Fang Wang, et al. Germline cytotoxic lymphocytes defective mutations in Chinese patients with lymphoma [J]. Oncology Letters,2017,14(5):5249-56. [DOI: 10.3892/ol.2017.6898]
18.@王磊,劉紅星,孫文利. HPLC-MS/MS法在骨髓移植患者全血CSA及AML1濃度測定中的應用[J]. 重慶醫學(xué),2017,46(23):3234-7. [DOI:10.3969/j.issn.1671-8348.2017.23.021]
19.@王磊,劉紅星,孫文利. HPLC-MS/MS在骨髓移植患者他克莫司血藥濃度檢測中的應用[J]. 現代檢驗醫學(xué)雜志,2017,32(2):126-30. [DOI:10.3969/j.issn.1671-7414.2017.02.035]
20.@王磊,孫文利,李培余,等. 環(huán)孢素A血藥濃度檢測方法比較分析[J]. 中華臨床醫師雜志:電子版.2017;11(3) :417-21. [DOI:10.3877/cma.j.issn.1674-0785.2017.03.013]
21.@姜春菲,劉梅,魏娜,等. 血液病基因檢測臨床應用的認知程度調研報告[J]. 國際臨床報告,2016,3(2):1-6. [DOI: 10.14725/gjcr.v3n2a1659]
22.@張陽(yáng),陳雪,王彤,等. 伴先天易感因素和復雜基因突變的難治復發(fā)兒童急性髓系白血病一例并文獻復習[J]. 白血病?淋巴瘤,2016,25(12):743-5. [DOI:10.3760/cma.j.issn.1009-9921.2016.12.010]
23.@王磊,周楓葉,姜春菲,等. HPLC-MS/MS法測定白血病患者血漿伊馬替尼和達沙替尼濃度[J]. 現代檢驗醫學(xué)雜志,2016,31(1):128-31. [DOI:10.3969/j.issn.1671-7414.2016.01.037]
約稿/專(zhuān)論/述評/綜述(近3年)
24.@Hongxing Liu, Yu Zhang. From Targeted Testing to Targeted Analysis: The Era of Comprehensive Clinical Genomics Analysis Is Coming. Genetics and Molecular Biology Research. 2018; 1(1): 3.
25.@Zhang Y, Wang F, Zhang Y, et al. Ongoing Development of Tumor Mutaome Analysis and Targeted Cocktail Therapy. J Clin Pathol Forecast. 2018; 1(1): 1001.
26.@Chen JQ, Wang F, Chen X, et al. The Rising Applications of Pharmacogenomics based Personalized Medication Fingerprints in Malignancies. J Clin Pathol Forecast. 2018; 1(1): 1002.
27.@劉紅星,王芳,聶代靜. 血液系統疾病基因組學(xué)分析及臨床應用進(jìn)展[J]. 白血病?淋巴瘤,2018,27(2):69-71. [DOI:10.3760/cma.j.issn.109-9921.2018.02.002]
28.@周曉蘇,鄭旺良,劉紅星. 基于腫瘤新生抗原的免疫治療在血液腫瘤中的應用前景[J]. 白血病?淋巴瘤,2018,27(2):80-2. [DOI:10.3760/cma.j.issn.109-9921.2018.02.005]
29.@張陽(yáng),劉銘,劉紅星. 骨髓增生異常綜合征中常見(jiàn)的基因突變及其臨床意義[J]. 臨床與病理雜志,2017,37(11): 2237-42. [DOI: 10.3978/j.issn.2095-6959.2017.10.035]
30.@張陽(yáng),劉紅星. 液體活檢在淋巴瘤中的研究和應用進(jìn)展[J]. 中國實(shí)驗血液學(xué)雜志,2017,25(4):125
9-63. [DOI:10.7534/j.issn.1009-2137.2017.04.054]
31.@陳雪,劉紅星. 精準理解和探究遺傳致病因素:從孟德?tīng)栠z傳病到遺傳易感[J]. 中華臨床醫師雜志:電子版.2017;11(3) :516-8. [DOI:10.3877/cma.j.issn.1674-0785.2017.03.036]
32.@劉紅星,陳雪,王芳. 免疫組庫分析在血液腫瘤中的研究和應用進(jìn)展[J]. 白血病?淋巴瘤,2017,
26(2):68-70. [DOI:10.3760/cma.j.issn.109-9921.2017.02.002]
33.@劉紅星,張陽(yáng),陳雪. 端粒和端粒酶在血液系統疾病中的研究進(jìn)展[J]. 白血病?淋巴瘤,2017, 25 (1):12-14. [DOI:10.3760/cma.j.issn.109-9921.2017.01.005]
34.@Yang Zhang, Yu Zhang, Hongxing Liu. Advances in Research and Application of Liquid Biopsy in Lymphoma. International Journal of Medical Reviews. 2016;3(4):501-503. [DOI: 10.15171/ijmr.2016.10]
35.@張陽(yáng),陳雪,劉紅星. 慢性粒細胞白血病靶向治療和靶向雞尾酒療法研究進(jìn)展[J]. 白血病?淋巴瘤,2016,25(10):632-6. [DOI:10.3760/cma.j.issn.109-9921.2016.10.018]
36.@周楓葉,張陽(yáng),劉紅星. 血液腫瘤相關(guān)藥物基因組學(xué)研究和應用進(jìn)展[J]. 中華臨床醫師雜志:電子版.2016;10(14) :2145-9. [DOI:10.3877/cma.j.issn.1674-0785.2016.14.023]
37.@張玉便,陳雪,劉紅星. 人類(lèi)皰疹病毒8型相關(guān)疾病及致病機制研究進(jìn)展[J]. 中華臨床醫師雜志:電子版.2016,10(14) :2180-3. [DOI:10.3877/cma.j.issn.1674-0785.2016.14.031]
38.@劉紅星,周楓葉,張陽(yáng). 血液腫瘤個(gè)體化用藥及相關(guān)遺傳藥物基因組學(xué)研究進(jìn)展[J]. 白血病?淋巴瘤,2016,25(7):385-8, 393. [DOI:10.3760/cma.j.issn.1009-9921.2016.07.001]
39.@陳雪,張陽(yáng),劉紅星. 陣發(fā)性睡眠性血紅蛋白尿癥發(fā)病機制、診斷及治療進(jìn)展[J]. 白血病?淋巴瘤,2016,25(4):252-6. [DOI:10.3760/cma.j.issn.1009-9921.2016.04.017]
40.@陳雪,竇丹丹,張陽(yáng),等. 兒童急性淋巴細胞白血病基因拷貝數變異研究及應用進(jìn)展:第57屆美國血液學(xué)會(huì )年會(huì )報道[J]. 白血病?淋巴瘤,2016,25(3):139-43. [DOI:10.3760/cma.j.issn.1009-9921.2016.03.003]
參與編寫(xiě)的國內專(zhuān)家共識
41.中國抗癌協(xié)會(huì )血液腫瘤專(zhuān)業(yè)委員會(huì )、中華醫學(xué)會(huì )血液學(xué)分會(huì )、中華醫學(xué)會(huì )病理學(xué)分會(huì ). 二代測序技術(shù)在血液腫瘤中的應用中國專(zhuān)家共識(2018年版)[J]. 中華血液學(xué)雜志,2018,39(11):881-6. [DOI:10.3760/cma.j.issn.0253-2727.2018.11.001]
42.中國醫師協(xié)會(huì )檢驗醫師分會(huì )造血與淋巴組織腫瘤檢驗醫學(xué)專(zhuān)家委員會(huì ). 造血與淋巴組織腫瘤檢驗診斷報告模式專(zhuān)家共識[J]. 中華醫學(xué)雜志,2016,96(12):918-29. [DOI:10.3760/cma.j.issn.0253-2727.2013.07.022]
43.中華醫學(xué)會(huì )血液學(xué)分會(huì )實(shí)驗診斷血液學(xué)學(xué)組. 血液病分子生物學(xué)診斷技術(shù)中國專(zhuān)家共識(2013年版)[J]. 中華血液學(xué)雜志,2013,34(7):643-6.
參編書(shū)籍
44.《臨床血液學(xué)檢驗》,人民衛生出版社,2017
45.《轉錄組學(xué)在精準醫學(xué)中的應用》,上海交通大學(xué)出版社,2017
46.《檢驗診斷報告體系與應用規范》,人民衛生出版社,2017
國際會(huì )議報告(報告人或通訊作者)(近3年)
1. Poster Presentation. Personalized Cyclosporine A disposition in One Patient with Allogeneic Hematopoietic Stem Cell Transplantation. The 2019 World Stem Cell Summit. Miami, America. Jan-23-2019.
2. Poster Presentation. Exploration of Nutritional Indicators in Different Transplantation Periods of Leukemia patients. The 2019 World Stem Cell Summit. Miami, America. Jan-23-2019.
3. Poster Presentation. Activated Infection Spectrums Analysis of Human Herpes Viruses in Patients with Various Immunodeficiencies. The 2019 World Stem Cell Summit. Miami, America. Jan-23-2019.
4. Poster Presentation. Development and Application of an Automatic Analysis and Surveillance Platform for Chrimerism in Donors and Recipients post allo-HSCT. The 2019 World Stem Cell Summit. Miami, America. Jan-23-2019.
5. Poster Presentation. Copy Number Monitoring from Tumor-Only Targeted Gene Sequencing in Hematological Malignancies. Abstract #4086. The 60th Annual Meeting of American Society of Hematology. San Diego, America. Dec-1-2018.
6. Poster Presentation. Analysis of Molecular Minimal Residual Disease in Patients with Acute Leukemia during Complete Remission. Abstract #2781. The 60th Annual Meeting of American Society of Hematology. San Diego, America. Dec-2-2018.
7. 特邀發(fā)言. CSF3R Mutations Are Highly Concomitant with Transcription Factor Genes Abnormalities in Acute Myeloid Leukemia. The International Conference on Disease Biomarkers and Precision Medicine-2018. Houston, Oct-23,2018.
8. Poster Presentation. Benefits in the Surveillance of the Copy Number of RUNX1 in childhood B-ALL Patients from Targeted Gene Sequencing. The 2018 American Society of Human Genetics Meeting. San Diego, Oct-17-2018.
9. Poster Presentation. Molecular Characteristic of FLT3 Mutations in Acute Leukemia. The 80th Annual Meeting of the Japanese Society of Hematology. Osaka, Japan. Oct-12-2017.
10. Poster Presentation. Correlation analysis of Gene Mutation and clinical characteristics in Myelodysplastic Syndrome. The 80th Annual Meeting of the Japanese Society of Hematology. Osaka, Japan. Oct-12-2017.
11. 特邀發(fā)言. CSF3R Mutations Are Frequently Associated with Abnormalities of RUNX1, CBFB, CEBPA, and NPM1 Genes in Acute Myeloid Leukemia. The 23rd World Congress on Advances in Oncology. Athens, Greece. Sep-21,2018.
12. Poster Presentation. Analysis of donor chimerism in fingernails of recipients after allogeneic hematopoietic stem cell transplantation. The 44th Annual Meeting of Korean Cancer Association. Seoul, Korea. Jun-22, 2018
13. Poster Presentation. Genetic variant spectrum in 265 Chinese patients with Hemophagocytic Lymphohistiocytosis: molecular analysis of PRF1, UNC13D, STX11, STXBP2, SH2D1A and XIAP. The 44th Annual Meeting of Korean Cancer Association. Seoul, Korea. Jun-21, 2018
14. Poster Presentation. Analysis of donor chimerism in fingernails of recipients after allogeneic hematopoietic stem cell transplantation. The 2018 World Stem Cell Summit. Miami, America. Jan-23-2018.
15. Poster Presentation. CSF3R Mutation in Acute Leukemia and MDS Patients. The 59th Annual Meeting of American Society of Hematology. Atlanta, America. Dec-10-2017.
16. Oral Presentation. Analyze 36 fusion genes in 6170 de novo acute leukemia and myeloid neoplasms cases during 14 years. The 79th Annual Meeting of the Japanese Society of Hematology. Tokyo, Japan. Oct-20-2017.
17. Poster Presentation. The study of the applicability of three statistical methods in IGH immune repertoire analysis. The 2017 American Society of Human Genetics Meeting. Orlando, Oct. 20, 2017.
18. Poster Presentation. Analysis of germ line predisposition in Chinese children with bone marrow failure. The 2017 American Society of Human Genetics Meeting. Orlando, Oct. 19, 2017.